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SQ-31765(SQ31765)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
SQ-31765(SQ31765)图片
CAS NO:138383-07-0
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
SQ-31765 (SQ31765) 是一种苯并氮杂钙通道阻滞剂。
Cas No.138383-07-0
别名SQ31765; SQ 31765
Canonical SMILESO=C1N(CCN(C)C)C2=CC=CC(C(F)(F)F)=C2C[C@@H](C3=CC=C(OC)C=C3)[C@H]1OC(C)=O
分子式C24H27F3N2O4
分子量464.48
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SQ-31765 is a benzazepine calcium channel blocker.

SQ-31765 (SQ 31,765) can reduce the severity of ischemia in a manner which is independent of changes in myocardial blood flow or hemodynamic alterations. Anesthetized dogs are given saline (n=6), SQ-31765 (n=6; 0.2 mg/kg) or SQ 32,189 (n=6; 0.2 mg/kg) i.v. 10 min before ischemia. The effect on pacing-induced ST-segment elevation (pacing+left anterior descending coronary artery stenosis) and myocardial blood flow are determined. SQ-31765 reduces ST-elevation (P<0.05) compared to saline at 10, 40 and 70 min after infusion (5.9±1.4 and 12.0±1.4 mV, respectively, at 70 min). Left anterior descending coronary artery stenosis during atrial pacing resulted in a significant reduction in subendocardial flow in all groups before drug infusion (41±7, 44±7 and 35±9 mL/min/100 g for saline, SQ-31765 and SQ 32,189, respectively)[1].

[1]. Grover GJ, et al. Anti-ischemic and vasorelaxant effects of the new benzazepine calcium channel blocker SQ 31,765. J Pharmacol Exp Ther. 1989 Dec;251(3):1020-5.