您好，欢迎来到试剂信息网！ [登录] [免费注册]
试剂信息网
发布求购
位置：首页 > 产品库 > DBCO-NHS ester 3
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
DBCO-NHS ester 3
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DBCO-NHS ester 3图片
CAS NO:1393350-27-0
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
DBCO-NHS ester 3 (Compound 12) 是一种用于制备抗体偶联药物 (ADC) 的可降解 linker。DBCO-NHS ester 3 是一种二苯基环辛酮 (DBCO) 衍生物，通过 MeOND 和 DIBAC 的羧酸部分被 N-羟基琥珀酰亚胺活化而获得的。
Cas No.1393350-27-0
分子式C24H20N2O5
分子量416.43
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DBCO-NHS ester 3 (Compound 12) is a cleavable linker that is used for making antibody-drug conjugate (ADC). DBCO-NHS ester 3 is a derivative of Dibenzylcyclooctyne (DBCO) obtained by activation of N-hydroxysuccinimide by the carboxylic acid moiety of both methyl-oxanorbornadiene (MeOND) and dibenzoazacyclooctyne (DIBAC)[1][2].

[1]. Silvie A. Meeuwissen, et al. Copper-free click chemistry on polymersomes: pre- vs. post-self-assembly functionalization. Polymer Chemistry. 2012, 3: 1783-1795.
[2]. Tang F, et al. Chemoenzymatic synthesis of glycoengineered IgG antibodies and glycosite-specific antibody-drug conjugates. Nat Protoc. 2017 Aug;12(8):1702-1721.