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Cepharanthine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cepharanthine图片
CAS NO:481-49-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
Cepharanthine 是从植物 Stephania cephalantha Hayata 中分离出来的天然产物。
Cas No.481-49-2
别名千金藤碱
Canonical SMILESCN1CCC2=CC3=C(C4=C2C1CC5=CC=C(C=C5)OC6=C(C=CC(=C6)CC7C8=CC(=C(C=C8CCN7C)OC)O4)OC)OCO3
分子式C37H38N2O6
分子量606.71
溶解度≥ 21.9mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 90 microM for the antiperoxidant potency

Cepharanthine is a biscoclaurine alkaloid extracted from Stephania cepharantha Hayata, which is widely used for the treatment of many acute and chronic diseases. The extract of Stephania cepharantha Hayata contains biscoclaurine alkaloids such as cepharanthine, which have been used widely for the treatment of radiation-induced leukopenia.

In vitro: Cepharanthine was found to exert antitumor effects by augmenting the immunological responses of the host, or by exerting apoptosis-inducing effects [1].

In vivo: Combined therapy of cepharanthine and S-1 (a new oral antineoplastic agent) showed antitumor effects on human OSCC xenografts and induced apoptotic cells in tumors significantly. Immunohistochemistry results showed TS and DPD expressions down-regulated and OPRT expression up-regulated in tumors treated with cepharanthine plus S-1 [2].

Clinical trial: In order to examine the clinical efficacy of cepharanthin for preventing chemotherapy-caused leukopenia in lung cancer patients, a randomized trial was carried out. The results suggested that administration of cepharanthin had an obvious antileukopenic effect in anticancer treatment, which made it possible to reduce the period of risk for infection and allow effective regimens to be repeatedly administered in a shorter interval [3].

References:
[1] Furusawa S,Wu J.  The effects of biscoclaurine alkaloid cepharanthine on mammalian cells: implications for cancer, shock, and inflammatory diseases. Life Sci.2007 Feb 27;80(12):1073-9.
[2] Harada K,Ferdous T,Itashiki Y,Takii M,Mano T,Mori Y,Ueyama Y.  Effects of cepharanthine alone and in combination with fluoropyrimidine anticancer agent, S-1, on tumor growth of human oral squamous cell carcinoma xenografts in nude mice. Anticancer Res.2009 Apr;29(4):1263-70.
[3] Saito R,Tsuchiya S,Ishizuka T,Fueki N,Ezawa K,Minato K,Nakano H,Takise A,Kurihara M,Fueki R.  Clinical effects of cepharanthin (Ceph.) on leukopenia by chemotherapy in lung cancer patients. Nihon Gan Chiryo Gakkai Shi.1989 Dec 20;24(11):2587-93.