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Apovincaminic acid hydrochloride salt
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Apovincaminic acid hydrochloride salt图片
CAS NO:72296-47-0
包装:5mg
市场价:2700元

产品介绍
Apovincaminicacidhydrochloridesalt是Vinpocetine(VP)的一种具有口服活性和可透过血脑屏障的主要活性代谢产物。Apovincaminicacidhydrochloridesalt具有神经保护作用。
Cas No.72296-47-0
Canonical SMILESCC[C@@]12[C@@]3([H])C4=C(CCN3CCC2)C5=CC=CC=C5N4C(C(O)=O)=C1.[H]Cl
分子式C20H23ClN2O2
分子量358.86
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action[1][2].

Apovincaminic acid (10 mg/kg; i.p. twice daily for 4 days) effectively attenuates the behavioral deficits, and significantly decreases lesion size and the region of microglia activation[1].Apovincaminic acid (10 mg/kg; p.o.) is absorbed 50% of the dose comparing with i.v. administration in rats[2]. Animal Model: Male Harlan‐Wistar rats (300-400 g) are injected NMDA[1]

[1]. Nyakas C, et, al. Neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on NMDA-induced neurotoxicity in a rat entorhinal cortex lesion model. CNS Neurosci Ther. Summer 2009;15(2):89-99. [2]. Pudleiner P, et, al. Study on the absorption of vinpocetine and apovincaminic acid. Eur J Drug Metab Pharmacokinet. Oct-Dec 1993;18(4):317-21. [3]. Wang M, et, al. Simultaneous Determination of Vinpocetine and its Major Active Metabolite Apovincaminic Acid in Rats by UPLC-MS/MS and its Application to the Brain Tissue Distribution Study. J Chromatogr Sci. 2018 Mar 1;56(3):225-232.