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2-Methylcitric acid trisodium
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2-Methylcitric acid trisodium图片
CAS NO:117041-96-0
包装:5mg
市场价:4320元

产品介绍
2-Methylcitricacidtrisodium(Methylcitricacidtrisodium)是2-甲基柠檬酸循环的内源性代谢物。2-Methylcitricacidtrisodium在甲基丙二酸血症和丙二酸酸血症中积累并能作为代谢标志物。2-Methylcitricacidtrisodium对谷氨酸支持的线粒体中ADP刺激和不耦合呼吸作用有明显的抑制作用。
Cas No.117041-96-0
别名Methylcitric acid trisodium
Canonical SMILESCC(C(O[Na])=O)C(C(O[Na])=O)(O)CC(O[Na])=O
分子式C7H7Na3O7
分子量272.1
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1].

2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria[1].2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM[1].2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca2+-loaded mitochondria supported by different substrates[1].2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis[1].2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport[1].2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria[1].

[1]. Palacios S, et al. Propionyl Coenzyme A Is a Common Intermediate in the 1,2-Propanediol and Propionate Catabolic Pathways Needed for Expression of the prpBCDE Operon during Growth of Salmonella enterica on 1,2-Propanediol. J Bacteriol. 2003 May;185(9):2802-10.