| 包装: | 100ug |
| 市场价: | 7790元 |
Recombinant Murine BMP-4 Protein is a TGF-beta superfamily ligand that is widely expressed from early embryogenesis through adulthood. Mouse BMP-4 shares 85% aa sequence identity with mouse BMP-2 and 35%-54% with other mouse BMPs. BMP-4 signals through tetrameric complexes composed of type I (primarily Activin RIA or BMPR-IA) and type II (primarily Activin RIIA or BMPR-II) receptors (11, 12). The bioavailability of BMP-4 is regulated by its interaction with multiple proteins and glycosaminoglycans.
Determine its activity by ATDC-5 cells induced production of alkaline phosphatase, the expected ED50 is 10-30 ng/mL.
Expression host is Human HEK293 cells
| 分子量 | |
| 分子式 | |
| CAS号 | |
| 纯度 | ≥95%, Endotoxin ≤0.01EU/ug |
| 溶解性（25°C） | Water Saline PBS |
| 储存和运输条件 | 2-8°C, dry, sealed 常温运输及临时存放 |
| 小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 | |
| 重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| 体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km系数 | 3 | 6 | 12 | 8 | 5 | 20 |
| 动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
| 动物 A的Km系数 |
例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。
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