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Corticosterone-d8
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Corticosterone-d8图片
CAS NO:1271728-07-4
包装:5mg
市场价:4158元

产品介绍
An internal standard for the quantification of corticosterone
Cas No.1271728-07-4
别名皮质酮 d8
Canonical SMILESO=C1C([2H])([2H])C[C@@]2(C)C(C([2H])([2H])C[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4([2H])C(C([2H])([2H])O)=O)=C1[2H]
分子式C21H22D8O4
分子量354.5
溶解度Ethanol: slightly soluble,Methanol: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Corticosterone-d8 is intended for use as an internal standard for the quantification of corticosterone by GC- or LC-MS. Corticosterone is a steroid hormone produced in the cortex of the adrenal glands that binds to both glucocorticoid and mineralocorticoid receptors.1 It is produced in response to adrenocorticotropic hormone (ACTH) and is the precursor to aldosterone synthesis.2 Since the production of glucocorticoids is increased by stress, it is often used as a biomarker of stress.3 Plasma corticosterone levels have a circadian variation and corticosterone may be important in the regulation of the sleep-wake cycle.4,5

|1. Lu, N.Z., Wardell, S.E., Burnstein, K.L., et al. International Union of Pharmacology. LXV. The pharmacology and classification of the nuclear receptor superfamily: Glucocorticoid, mineralocorticoid, progesterone, and androgen receptors. Pharmacol. Rev. 58(4), 782-797 (2006).|2. Palme, R., Rettenbacher, C., Touma, C., et al. Stress hormones in mammals and birds: Comparative aspects regarding metabolism, excretion, and noninvasive measurement in fecal samples. Ann. N.Y. Acad. Sci. 1040(21), 162-171 (2005).|3. Goymann, W., M•stl, E., and Gwinner, E. Corticosterone metabolites can be measured noninvasively in excreta of European stonechats (Saxicola torquata rubicola). Auk 119(4), 1167-1173 (2002).|4. VÁzquez-Palacios, G., Retana-MÁrquez, S., Bonilla-Jaime, H., et al. Further definition of the effect of corticosterone on the sleep-wake pattern in the male rat. Pharmacol. Biochem. Behav. 70(2-3), 305-310 (2001).|5. Millspaugh, J.J., Washburn, B.E., Milanick, M.A., et al. Effects of heat and chemical treatments on fecal glucocorticoid measurements: Implications for sample transport. Wildl. Soc. Bull. 31(2), 399-406 (2003).