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Des(benzylpyridyl)Atazanavir
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Des(benzylpyridyl)Atazanavir图片
CAS NO:1192224-24-0
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Des(benzylpyridyl) Atazanavir (compound M1) 是 Atazanavir 代谢物的 N-脱烷基化产物。
Cas No.1192224-24-0
Canonical SMILESO[C@@H](CNNC([C@@H](NC(OC)=O)C(C)(C)C)=O)[C@@H](NC([C@H](C(C)(C)C)NC(OC)=O)=O)CC1=CC=CC=C1
分子式C26H43N5O7
分子量537.7
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Des(benzylpyridyl) atazanavir is a major metabolite of the HIV-1 protease inhibitor atazanavir .1,2 It is formed from atazanavir by the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2D6.2

|1. ter Heine, R., Hillebrand, M.J.X., Rosing, H., et al. Identification and profiling of circulating metabolites of atazanavir, a HIV protease inhibitor. Drug Metab. Dispos. 37(9), 1826-1840 (2009).|2. Li, F., Lu, J., Wang, L., et al. CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism. Drug Metab. Dispos. 39(3), 394-401 (2011).