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SR 16832
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
SR 16832图片
CAS NO:2088135-12-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
SR 16832 是一种双位点共价 PPARγ 抑制剂，作用于正构和变构位点 。
Cas No.2088135-12-8
Canonical SMILESCOC1=CC=C2C(C(NC(C3=CC([N+]([O-])=O)=CC=C3Cl)=O)=CC=N2)=C1
分子式C17H12ClN3O4
分子量357.7
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SR 16832 is a dual-site covalent antagonist of peroxisome proliferator-activated receptor γ (PPARγ).1 It inhibits MRL20-induced allosteric activation of PPARγ in a reporter assay using HEK293T cells when used at a concentration of 5 μM. SR 16832 also reduces basal activity of PPARγ and inhibits binding of docosahexaenoic acid to PPARγ in a time-resolved FRET (TR-FRET) assay.

References
1. Brust, R., Lin, H., Fuhrmann, J., et al. Modification of the orthosteric PPARγ covalent antagonist scaffold yields an improved dual-site allosteric inhibitor. ACS Chem. Biol. 12(4), 969-978 (2017).