CAS: | 908112-43-6 |
分子式: | C23H27F3N4O3 |
分子量: | 464.48 |
纯度: | ≥98% |
溶解性: | DMSO |
存储: | Powder -20℃ 3 years; 4℃ 2 years In solvent -80℃ 6 months;-20℃ 1 month |
研究领域: | Cancer |
Target: | IC50: 10 nM (Her-2)[1], 30 nM (Hsp90 α), 30 nM (Hsp90 β), 4.275 μM (Grp94), 0.862 μM (Trap-1)[2]Kd: 16 nM (Hsp90)[1] |
描述: | SNX-2112 is an orally active Hsp90 inhibitor, with a Kd of 16 nM for Hsp90 and IC50 of 30 nM, 30 nM for Hsp90 α and Hsp90 β, also induces Her-2 degradation, and inhibits Grp94 and Trap-1, with IC50 of |