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BGG463
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BGG463图片
CAS NO:890129-26-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
BGG463 (K03859) 是一种具有口服活性的 II 型 CDK2 抑制剂。
Cas No.890129-26-7
别名K03859
Canonical SMILESO=C(C1=C2C=CC(OC3=NC=NC(NC(C)=O)=C3)=CC2=CC=C1)NC4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4
分子式C30H29F3N6O3
分子量578.58
溶解度DMSO : ≥ 125 mg/mL (216.05 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

BGG463 (K03859) is an orally active type II CDK2 inhibitor[1].

BGG463 potently inhibits T315I BCR–ABL autophosphorylation and shows good oral efficacy in mouse models of CML[2].

References:
[1]. Alexander LT, et al. Type II Inhibitors Targeting CDK2. ACS Chem Biol. 2015 Sep 18;10(9):2116-25.
[2]. Jones K, et al. Cancer Drug Discovery 2010: from molecules to medicine. Expert Rev Clin Pharmacol. 2010 Sep;3(5):613-5.