Neticonazole hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

130773-02-3

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

Neticonazole hydrochloride 是一种咪唑衍生物，也是一种有效且长效的抗真菌剂。 Neticonazole hydrochloride 也是一种口服活性的外泌体生物合成及释放 (exosome biogenesis and secretion) 抑制剂。Neticonazole hydrochloride 具有抗感染和抗癌作用。

Cas No.	130773-02-3
别名	盐酸奈替康唑
Canonical SMILES	CCCCCOC1=CC=CC=C1/C(N2C=CN=C2)=C\SC.[H]Cl
分子式	C₁₇H₂₃ClN₂OS
分子量	338.9
溶解度	DMSO: 250 mg/mL (737.68 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Neticonazole hydrochloride is an imidazole derivative and a potent and long-acting antifungal agent. Neticonazole hydrochloride is also an orally active exosome biogenesis and secretion inhibitor. Neticonazole hydrochloride has anti-infection and anti-cancer effects[1][2][3]. [1]. Tsuboi R, et al. Hyperkeratotic chronic tinea pedis treated with neticonazole cream. Neticonazole Study Group. Int J Dermatol. 1996 May;35(5):371-3. [2]. Datta A, et al. High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: A drug repurposing strategy for advanced cancer. Sci Rep. 2018 May 25;8(1):8161. [3]. Gu L, et al. The exosome secretion inhibitor neticonazole suppresses intestinal dysbacteriosis-induced tumorigenesis of colorectal cancer. Invest New Drugs. 2020 Apr;38(2):221-228.