SCH900776 S-异构体是SCH900776的S-异构体。 SCH900776 是一种有效的、选择性的、具有口服生物利用度的检查点激酶1 (Chk1) 抑制剂，IC50 为 3 nM。
| Cas No. | 891494-64-7 |
| 别名 | SCH 900776 S-isomer;SCH-900776 S-isomer |
| 化学名 | (S)-6-bromo-3-(1-methyl-1H-pyrazol-4-yl)-5-(piperidin-3-yl)pyrazolo[1,5-a]pyrimidin-7-amine |
| Canonical SMILES | NC1=C(Br)C([C@@H]2CNCCC2)=NC3=C(C4=CN(C)N=C4)C=NN13 |
| 分子式 | C15H18BrN7 |
| 分子量 | 376.25 |
| 溶解度 | ≥ 37.6 mg/mL in DMSO, ≥ 47.8 mg/mL in EtOH with ultrasonic |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SCH900776 is a potent, selective and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50 = 3 nM), highly selective against Chk2 (IC50 = 1500 nM) and cyclin-dependent kinase CDK2 (IC50 = 160 nM). SCH900776 exposure phenocopies short interfering RNA-mediated CHK1 ablation and interacts synergistically with DNA antimetabolite agents in vitro and in vivo to selectively induce dsDNA breaks and cell death in tumor cell backgrounds. Chk1 inhibitor SCH 900776 abrogates cytarabine-induced S-phase arrest and enhances cytarabine cytotoxicity in acute leukemia cell lines and leukemic blasts in vitro. |
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