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STING Agonist 12b
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
STING Agonist 12b图片
CAS NO:2411100-70-2
包装与价格：
包装价格(元)
500 μg电议
1mg电议
5mg电议
10mg电议

产品介绍
A STING agonist
Cas No.2411100-70-2
Canonical SMILESO=C1C2=CC=C(C)C(C)=C2NC3=CC=C(C=C13)OC
分子式C16H15NO2
分子量253.3
溶解度DMF: 1 mg/ml,DMSO: 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

STING agonist 12b is an agonist of stimulator of interferon genes (STING).1It binds to STING (Kd= 26.4 µM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 µM, respectively). STING agonist 12b (40 µM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells.

1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)