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Tilapertin(AMG747)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tilapertin(AMG747)图片
CAS NO:1000690-85-6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Tilapertin (AMG747) 是一种甘氨酸转运蛋白 1 型 (GlyT1) 的口服抑制剂。
Cas No.1000690-85-6
别名AMG747
Canonical SMILESO=C(O)CN1CCN([C@H](C2=CC=CC=C2)C3=CC=CC(C(F)(F)F)=C3)CC1
分子式C20H21F3N2O2
分子量378.39
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tilapertin is an oral inhibitor of glycine transporter type-1 (GlyT1).

Tilapertin is a nanomolar potent, orally bioavailable and selective GlyT1 inhibitor. Oral administration of Tilapertin dose-dependently increases cerebrospinal fluid (CSF) glycine concentration in rats[1].

[1]. Dunayevich E, et al. Efficacy and safety of the glycine transporter type-1 inhibitor AMG 747 for the treatment of negative symptoms associated with schizophrenia. Schizophr Res. 2017 Apr;182:90-97.