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CP-409092
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CP-409092图片
CAS NO:194098-25-4
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
20mg电议

产品介绍
CP-409092是GABA(A)的部分激动剂,主要用于抗焦虑研究。
Cas No.194098-25-4
Canonical SMILESO=C(C1=CNC2=C1C(CCC2)=O)NC3=CC=C(CNC)C=C3
分子式C17H19N3O2
分子量297.35
溶解度DMSO: 41.67 mg/mL (140.14 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CP-409092 is a GABA(A) partial agonist, used for the treatment of anxiety.

The pharmacokinetics of CP-409,092 following single intravenous and oral doses of 4 and 15 mg/kg, respectively, are characterized by high clearance of 169+ or -18 mL/min/kg, a volume of distribution of 8.99+ or -1.46 L/kg, and an oral bioavailability of 2.9%+ or -3%. Following oral administration of 100 mg/kg [14C]CP-409,092, the total recovery is 89.1%+ or -3.2% for male rats and 89.3%+ or -0.58% for female rats[1].

[1]. Kamel A, et al. Metabolism, pharmacokinetics and excretion of the GABA(A) receptor partial agonist [(14)C]CP-409,092 in rats. Xenobiotica. 2010 Jun;40(6):400-14.