| CAS NO: | 1196732-52-1 |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 1g | 电议 |
| Cas No. | 1196732-52-1 |
| 分子式 | C19H37NO8 |
| 分子量 | 407.5 |
| 储存条件 | 4°C, protect from light, stored under nitrogen |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Propargyl-PEG8-NH2 (compound 3b) is a PEG-basedPROTAC linkercan be used in the synthesis of PROTACs. Propargyl-PEG8-NH2 is a non-cleavableADC linkerused in the synthesis of antibody-drug conjugates (ADCs)[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. [1]. Genady AR, et al. Preparation and Evaluation of Radiolabeled Antibody Recruiting Small Molecules That TargetProstate-Specific Membrane Antigen for Combined Radiotherapy and Immunotherapy. J Med Chem. 2016 Mar 24;59(6):2660-73. |
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