Molecular Weight (MW)

397.43

Formula

C22H19N7O

CAS No.

900185-01-5

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: 80 mg/mL (201.3 mM)

Water:<1 mg/mL

Ethanol: <1 mg/mL

Other info

InChi Key: KQDBVHKNIYROHU-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H19N7O/c1-13-6-3-4-9-17(13)29-18(27-16-8-5-7-14(2)19(16)22(29)30)11-28-21-15(10-26-28)20(23)24-12-25-21/h3-10,12H,11H2,1-2H3,(H2,23,24,25)
SMILES Code: O=C1N(C2=CC=CC=C2C)C(CN3N=CC4=C(N)N=CN=C43)=NC5=C1C(C)=CC=C5

Chemical Name

2-((4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one; PIK-293; PIK 293; PIK293

In Vitro

Kinase Assay: PIK-293 is a PI3K inhibitor, mostly for PI3Kδ with IC50 of 0.24 μM, 500-, 100- and 50-fold less potent to PI3Kα/β/γ, respectively. PIK-293 inhibits the p110α, p110β, p110δ, and p110γ with IC50 of 100 μM, 25 μM, 0.24 μM,and 10 &kkkmu;M. PIK-293 is the parent compound of PIK-294.

Cell Assay: PIK-293 is a pyrazolopyrimidine analog of IC87114. PIK-293 is synthesized by replacing the adenine of IC87114 with the isosteric pyrazolopyrimidine.

In Vivo

Animal model

Formulation & Dosage

References

[1] Knight ZA et al. Cell, 2006, 125(4), 733-747.