CAS NO: | 4871-97-0 |
包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
20mg | 电议 |
Cas No. | 4871-97-0 |
别名 | 姜黄醇; (-)-Curcumol |
化学名 | (3S,5S,6S,8aS)-5-isopropyl-3-methyl-8-methyleneoctahydro-1H-3a,6-epoxyazulen-6-ol |
Canonical SMILES | [H][C@]12C(C([H])([H])[C@@]3([H])C(C([H])([H])[H])([H])C([H])([H])[H])([C@](C([H])([H])[H])([H])C([H])([H])C1([H])[H])O[C@]3(C([H])([H])/C2=C([H])\[H])O[H] |
分子式 | C15H24O2 |
分子量 | 236.35 |
溶解度 | ≥ 9.4mg/mL in DMSO |
储存条件 | Store at 4°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Curcumol is a sesquiterpene originally isolated from curcuma rhizomes; shows anticancer activities both in vitro and in vivo.IC50 value:Target: Anticancer natural compoundin vitro: Curcumol exhibited time- and concentration-dependent anti-proliferative effects in SPC-A-1 human lung adenocarcinoma cells with cell cycle arrest in the G0/G1 phase while apoptosis-induction was also confirmed with flow cytometry and morphological analyses [1]. Curcumol-induced growth inhibition correlated with apoptosis induction as evidenced by Annexin V staining, and cleavage of caspase-3 and poly (ADP-ribose) polymerase (PARP) in HSC-T6. Suppression of the NF-κB translocation via inhibition of IκB-α phosphorylation by the curcumol led to the inhibition of expression of NF-κB-regulated gene, e.g. Bcl-xL and Bcl-2, in a PI3K-dependent manner, which is upstream of NF-κB activation [2]. Curcumol exhibits an inhibitory effect on receptor activator of nuclear factor kappaB ligand (RANKL)-induced osteoclast differentiation with both bone marrow-derived macrophages and RAW264.7 cells in a dose-dependent manner [3].in vivo: Anti-neoplastic effects of curcumol were also confirmed in tumor bearing mice. Curcumol (60 mg/kg daily) significantly reduced tumor size without causing notable toxicity [1]. References: |