Molecular Weight (MW)

302.24

Formula

C15H10O7

CAS No.

117-39-5

Storage

-20℃ for 3 years in powder form

-80℃ for 2 years in solvent

Solubility (In vitro)

DMSO: 61 mg/mL (201.8 mM)

Water:<1 mg/mL

Ethanol: 10 mg/mL (33.1 mM)

Other info

Synonym: NCI-C60106; NSC 9219; NSC 9221; Kvercetin; Meletin; Quercetin; Quercetine; Quercetol; Quertine; Sophoretin; Xanthaurine.

InChi Key: REFJWTPEDVJJIY-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H

SMILES Code: O=C1C(O)=C(C2=CC=C(O)C(O)=C2)OC3=CC(O)=CC(O)=C13

Chemical Name

2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one

In Vitro

Kinase Assay: Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation.

Cell Assay: Quercetin is a type of plant-based chemical, or phytochemical, known as a flavonol and a plant-derived flavonoid found in fruits, vegetables, leaves and grains. It also may be used as an ingredient in supplements, beverages or foods. In several studies, it may have anti-inflammatory and antioxidant properties, and it is being investigated for a wide range of potential health benefits. Quercetin (Sophoretin) is a PI3K inhibitor with IC50 of 2.4 – 5.4 μM. It strongly abrogated PI3K and Src kinases, mildly inhibited Akt1/2, and slightly affected PKC, p38 and ERK1/2. Quercetin inhibits TNF-induced LDH% release, EC-dependent neutrophils adhesion to bovine pulmonary artery endothelial cells (BPAEC), and BPAEC DNA synthesis and proliferation.

In Vivo

Combination of Quercetin (75 mg/kg) and 2-Methoxyestradiol enhances inhibition of human prostate cancer LNCaP and PC-3 cells xenograft tumor growth. LD50:>3000mg/kg (i.g.)

Animal model

Mice bearing LNCaP xenografts or PC-3 xenografts

Formulation & Dosage

Dissolved in 25% hydroxypropyl-β-cyclodextrin; 75 mg/kg

References

[1] Yang F, et al. PLoS One. 2015, 10(5), e0128277.

Quercetin combined with 2-ME enhanced inhibition of PC-3 xenograft tumor growth. Yang F, et al. PLoS One. 2015, 10(5), e0128277.

Quercetin combined with 2-ME decreased pAKT protein expression in PC-3 and LNCaP xenograft tumor tissues.

Quercetin combined with 2-ME decreased VEGF protein and mRNA in PC-3 and LNCaP xenograft tumor tissues.