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IKK2 Inhibitor VI
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
IKK2 Inhibitor VI图片
CAS NO:354811-10-2
包装与价格：
包装价格(元)
500μg电议
1mg电议
5mg电议

产品介绍
Cas No.354811-10-2
别名5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide
化学名2-[(aminocarbonyl)amino]-5-phenyl-3-thiophenecarboxamide
Canonical SMILESO=C(N)NC1=C(C(N)=O)C=C(C2=CC=CC=C2)S1
分子式C12H11N3O2S
分子量261.3
溶解度2mg/mL in ethanol, 30mg/mL in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Inhibitor of NF-κB kinase 2 (IKK2, also known as IKKβ) acts as part of an IKK complex in the canonical NF-κB pathway, phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. NF-κB signaling can also occur through a non-canonical, IKK/IκB-independent pathway. IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM). [1] It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.[2][3]

Reference:
[1]. Baxter, A., Brough, S., Cooper, A., et al. Hit-to-lead studies: The discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorganic & Medicinal Chemistry Letters 14, 2817-2822 (2004).
[2]. McNamara, L.A., Ganesh, J.A., and Collins, K.L. Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation. Journal of Virology 86(17), 9337-9350 (2012).
[3]. Punj, V., Matta, H., and Chaudhary, P.M. A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma. PLoS One 7(5), 1-15 (2012).