| CAS NO: | 101043-37-2 |
| 包装 | 价格(元) |
| 50 μg(0.5 mM * 100 μL in Ethanol) | 电议 |
| 100 μg(0.5 mM * 200 μL in Ethanol) | 电议 |
Microcystin-LR 是蛋白磷酸酶 1 型和 2A 型 (PP1/2A) 的有效抑制剂，其 IC50 值分别为 1.7 nM，0.04 nM。
| Cas No. | 101043-37-2 |
| 别名 | 微囊藻毒素(LR亚型),Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa) |
| 化学名 | cyclo[2,3-didehydro-N-methylalanyl-D-alanyl-L-leucyl-(3S)-3-methyl-D-β-aspartyl-L-arginyl-(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-γ-glutamyl] |
| Canonical SMILES | CC(/C=C/[C@@H]([C@@H](C(N[C@H](CCC(N(C(C(N[C@@H]1C)=O)=C)C)=O)C(O)=O)=O)C)NC([C@@H](NC([C@H]([C@@H](NC([C@](NC1=O)([H])CC(C)C)=O)C(O)=O)C)=O)CCCNC(N)=N)=O)=C\[C@H](C)[C@@H](OC)CC2=CC=CC=C2 |
| 分子式 | C49H74N10O12 |
| 分子量 | 995.17 |
| 溶解度 | DMSO: 10 mg/ml,Ethanol: 10 mg/ml,Methanol: 10 mg/ml |
| 储存条件 | Store at -20℃, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 文献引用 | |
| 产品描述 | Microcystins are hepatotoxic cyclic heptapeptide toxins produced by cyanobacteria.[1] They are responsible for periodic poisonings of humans and livestock drinking fresh water where the blue-green algae are endemic. Microcystin-LR is a selective inhibitor of protein phosphatase 2A (PP2A) (IC50= 0.04 nM) and will completely inhibit this enzyme without affecting PP1 when used at a concentration of 0.5 nM.[2] The PP1 IC50 is about 1.7 nM. Microcystins are at least 10 times more potent as serine/threonine PP inhibitors than okadaic acid, another microalgal toxin also used for this purpose. Reference: |
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