| CAS NO: | 529-69-1 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
interferes with RNA and DNA synthesis
| Cas No. | 529-69-1 |
| 别名 | 異黃喋呤,NSC 118090,NSC 614991 |
| 化学名 | 2-amino-4,7(3H,8H)-pteridinedione |
| Canonical SMILES | O=C1C=NC(C(N=C(N)N2)=O)=C2N1 |
| 分子式 | C6H5N5O2 |
| 分子量 | 179.1 |
| 溶解度 | ≤5mg/L in Water |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Isoxanthopterin interferes with RNA and DNA synthesis. Isoxanthopterin, a natural intermediate in the pteridine pathway, plays critical roles in pigmentation and cell division. In vitro: Isoxanthopterin was identified as a pteridine of wide natural occurrence and was reported to exerts an inhibitory action on the synthesis of ribosomal RNA, possibly soluble RNA and on DNA in developing eggs of the milkweed bug Oncopeltus fasciatus. Such effects were measured by partially incubating dechorionated eggs in a solution containing isoxanthopterin and radioactive uridine or thymidine, and then testing the incorporation of the isotope into ribosomal RNA or DNA. The detailed mechanism of this inhibition had been discussed, and the tentative conclusion was agreed that it was due to an interaction between the pteridine and the nucleic acid (most probably DNA) [1]. In vivo: Previous animal study showed that rats with inherited retinal dystrophy appeared to differ from healthy rats by an elevated isoxanthopterin excretion in urine. RCS rats responded to feeding of monapterin with an increase of isoxanthopterin excretion. This phenomenon supported the idea that the RCS rat had an increased xanthinoxidase activity compared with healthy rats [2]. Clinical trial: So far, no clinical study has been conducted. References: |
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