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D-64131
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
D-64131图片
CAS NO:74588-78-6
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
D-64131 是一种具有口服活性的微管蛋白抑制剂,对微管蛋白聚合的 IC50 为 0.53 μM。 D-64131 具有抗有丝分裂活性。 D-64131 可用于癌症研究。
Cas No.74588-78-6
别名D 64131;D64131
化学名(5-methoxy-1H-indol-2-yl)(phenyl)methanone
Canonical SMILESCOC1=CC2=C(C=C1)NC(=C2)C(=O)C3=CC=CC=C3
分子式C16H13NO2
分子量251.28
溶解度DMF: 33 mg/ml,DMF:PBS (pH 7) (1:10): 0.16 mg/ml,DMSO: 25 mg/ml
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

D-64131 is a novel inhibitor of Tubulin polymerization that competitively binds with [(3)H]colchicine to αβ-Tubulin. IC50 Value: N/ATarget: Microtubule/Tubulinin vitro: D-64131 is cytotoxic and inhibits tumor cell proliferation in vitro (IC50 = 74 nM). D-64131 prevents growth of tumor models in mice following oral administration in vivo. D-64131 has significant potential in cancer treatment. The proliferation of tumor cells from 12 of 14 different organs and tissues was inhibited with mean IC(50)s of 62 nM by D-64131.in vivo: In animal studies, no signs of systemic toxicity were observed after p.o. dosages of up to 400 mg/kg of D-64131. In xenograft experiments with the human amelanoic melanoma MEXF 989, D-64131 was highly active with treatment resulting in a growth delay of 23.4 days at 400 mg/kg. Therefore, D-64131 and analogues have the potential to be developed for cancer therapy, replacing or supplementing standard therapy regimens with tubulin-targeting drugs from natural sources.

References:
[1]. Mahboobi, Siavosh; Pongratz, Herwig; Hufsky, Harald et al. Synthetic 2-Aroylindole Derivatives as a New Class of Potent Tubulin-Inhibitory, Antimitotic Agents. Journal of Medicinal Chemistry (2001), 44(26), 4535-4553.
[2]. Bacher, G.; Beckers, T.; Emig, P. et al. New small-molecule tubulin inhibitors. Pure and Applied Chemistry (2001), 73(9), 1459-1464.
[3]. Beckers, Thomas; Reissmann, Thomas; Schmidt, Mathias et al. 2-Aroylindoles, a novel class of potent, orally active small molecule tubulin inhibitors. Cancer Research (2002), 62(11), 3113-3119.