Deacetyltaxol

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Deacetyltaxol

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	78432-77-6
包装:	20mg
市场价:	1575元

产品介绍

Deacetyltaxol (10-Deacetylpaclitaxel) 是一种从红豆杉 Zucc 中分离出来的紫杉烷衍生物。 Deacetyltaxol (10-Deacetylpaclitaxel) 促进微管蛋白的聚合，并抑制体外冷或钙离子诱导的微管解聚。 Deacetyltaxol (10-Deacetylpaclitaxel) 在人类胶质细胞和神经母细胞瘤细胞系中表现出细胞毒性。

Cas No.	78432-77-6
别名	10-去乙酰紫杉醇; 10-Deacetylpaclitaxel
Canonical SMILES	CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)O)C)O
分子式	C₄₅H₄₉NO₁₃
分子量	811.87
溶解度	≥ 81.2mg/mL in DMSO
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	10-Deacetyltaxol (10-Deacetylpaclitaxel) is a taxane derivative isolated from Taxus wallichiana Zucc[1]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) promotes the polymerization of tubulin and to inhibit the depolymerization of microtubules induced by cold or by calcium ions in vitro[2]. 10-Deacetyltaxol (10-Deacetylpaclitaxel) exhibits cytotoxicity in human glial and neuroblastoma cell-lines[3]. References: [1]. 19-Hydroxybaccatin III, 10-deacetylcephalomannine, and 10-deacetyltaxol: new antitumor taxanes from Taxus wallichiana. J Nat Prod. 1981 May-Jun;44(3):312-9. [2]. Michel Colin, et al. Process for the preparation of taxol and 10-deacetyltaxol. US4857653A. [3]. Helson L. Cephalomannine and 10-deacetyltaxol cytotoxicity in human glial and neuroblastoma cell-lines. Int J Oncol. 1993 Feb;2(2):297-9.