| CAS NO: | 93957-55-2 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 200mg | 电议 |
| Cas No. | 93957-55-2 |
| 别名 | 氟伐他汀钠,XU 62-320 |
| 化学名 | sodium;7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate |
| Canonical SMILES | CC(C)N1C2=CC=CC=C2C(=C1C=CC(CC(CC(=O)[O-])O)O)C3=CC=C(C=C3)F.[Na+] |
| 分子式 | C24H25FNNaO4 |
| 分子量 | 433.45 |
| 溶解度 | 50 mg/mL in Water (Need ultrasonic); 50 mg/mL in DMSO (Need ultrasonic) |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Fluvastatin sodium is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase [1]. Fluvastatin is a drug used to treat patients with hypercholesterolaemia. It lowers serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) as well as the serum apolipoprotein B. It also increases high density lipoprotein cholesterol (HDL-C) levels and apolipoprotein A-I levels. In addition to these, fluvastatin has antiatherogenic, antithrombotic and antioxidant effects. In U937 human monocyte cells, fluvastatin reduces the expression of adhesion molecules thus reducing the interaction between monocytes and endothelial cells. Fluvastatin dose-dependently reduces the platelet aggregation in vitro. The administration of fluvastatin at dose of 40 mg/day to patients reduces platelet aggregation by 10 to 15% after 4 to 24 weeks. In patients with hypercholesterolaemia, fluvastatin 40 mg/day for 8 weeks can reduce copper-induced diene production in LDL-C isolated from these patients. It is also reported that, fluvastatin can inhibit the production of NO and decreases inflammatory angiogenesis induced by the sponge matrix [1, 2]. References: |
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