| CAS NO: | 72873-74-6 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| Storage | Store at -20°C |
| M.Wt | 297.35 |
| Cas No. | 72873-74-6 |
| Formula | C16H12FN3S |
| Solubility | ≥14.3 mg/mL in DMSO |
| Chemical Name | 6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroimidazo[2,1-b]thiazole |
| Canonical SMILES | FC1=CC=C(C=C1)C2=C(N3C(SCC3)=N2)C4=CC=NC=C4 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
SKF-86002 是一种具有口服活性的p38 MAPK抑制剂，具有抗炎、抗关节炎和镇痛活性。SKF-86002能抑制脂氧合酶和环氧合酶介导的花生四烯酸代谢[1][2]。SKF-86002抑制LPS诱导的人类单核细胞中IL-1和TNF-α的产生（IC50：1μM）。
参考文献：
[1]. Frasch SC, Nick JA, Fadok VA, Bratton DL, Worthen GS, Henson PM. p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils. J Biol Chem. 1998 Apr 3;273(14):8389-97. doi: 10.1074/jbc.273.14.8389. PMID: 9525949.
[2]. Griswold DE, Marshall PJ, Webb EF, Godfrey R, Newton J Jr, DiMartino MJ, Sarau HM, Gleason JG, Poste G, Hanna N. SK&F 86002: a structurally novel anti-inflammatory agent that inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid. Biochem Pharmacol. 1987 Oct 15;36(20):3463-70. doi: 10.1016/0006-2952(87)90327-3. PMID: 2823821.
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