| CAS NO: | 39800-16-3 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 293.08 |
| Cas No. | 39800-16-3 |
| Formula | C7H15Cl2N2O4P |
| Solubility | Soluble in chloroform |
| Chemical Name | 2-(bis(2-chloroethyl)amino)-4-hydroperoxy-1,3,2-oxazaphosphinane 2-oxide |
| Canonical SMILES | O=P1(N(CCCl)CCCl)OCCC(OO)N1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
4-hydroperoxy Cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. It crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS)[1]. Formulations containing the prodrug Cyclophosphamide are used to treat lymphomas and autoimmune disorders[2,3].
References:
[1]. Strauss G, Westhoff M A, Fischer-Posovszky P, et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ, 2008, 15(2): 332-343.
[2]. Ahmed A R, Hombal S M. Cyclophosphamide (Cytoxan). A review on relevant pharmacology and clinical uses. J. Am. Acad. Dermatol, 1984, 11(6): 1115-1126.
[3]. Appel G B. New and future therapies for lupus nephritis. Cleve. Clin. J. Med, 2012, 79(2): 134-140.
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