| CAS NO: | 181530-09-6 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 414.47 |
| Cas No. | 181530-09-6 |
| Formula | C21H22N2O5S |
| Solubility | ≤0.5mg/ml in ethanol;25mg/ml in DMSO;30mg/ml in dimethyl formamide |
| Chemical Name | ethyl 2-((2-methyl-8-(4-methylphenylsulfonamido)quinolin-6-yl)oxy)acetate |
| Canonical SMILES | CC1=CC=C(S(NC2=C(N=C(C)C=C3)C3=CC(OCC(OCC)=O)=C2)(=O)=O)C=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Zinquin ethyl ester, a cell-permeable, quinolone-based fluorescent probe, is commonly used as a zinc indicator [1].
Zinc is an important component of many enzymes, transcription factors, and other functional proteins, where it exerts specific actions over a wide range of physiological processes, such as growth, development, and functioning of the endocrine, immune, and nervous systems, and may contribute to the development of tumors [2].
In pig kidney LLC-PK1 cells treated with diethylamine NONOate (DEA-NO), 20 μM zinquin ethyl ester was used for detection of Zn2+ release [1]. In normal human prostate epithelial (NHPrE) cells, 25 μM zinquin ethyl ester was used to quantify the free labile zinc level, emitting four times stronger fluorescence than zinquin [2]. In wild-type murine aortic endothelial cells, zinquin ethyl ester at the concentration of 25 μM, was employed to track intranuclear Zn2+ release, triggered by NO which was derived from the inducible NO synthase activity [3].
References:
[1]. Karim M R, Petering D H. Detection of Zn2+ release in nitric oxide treated cells and proteome: dependence on fluorescent sensor and proteomic sulfhydryl groups. Metallomics, 2017, 9(4): 391-401.
[2]. Zhang J J, Wu M, Schoene N W, et al. Effect of resveratrol and zinc on intracellular zinc status in normal human prostate epithelial cells. American Journal of Physiology-Cell Physiology, 2009, 297(3): C632-C644.
[3]. Spahl D U, Berendji-Grün D, Suschek C V, et al. Regulation of zinc homeostasis by inducible NO synthase-derived NO: nuclear metallothionein translocation and intranuclear Zn2+ release. Proceedings of the National Academy of Sciences of the United States of America, 2003, 100(24): 13952-13957.
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