MitoTEMPO(hydrate)

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MitoTEMPO(hydrate)

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1569257-94-8

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
25mg	电议

产品介绍

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	528.04
Cas No.	1569257-94-8
Formula	C₂₉H₃₇ClN₂O₃P
Solubility	≤15mg/ml in ethanol;10mg/ml in DMSO;15mg/ml in dimethyl formamide
Chemical Name	A name could not be generated for this structure.
Canonical SMILES	O=C(NC1CC(C)(C)N([O])C(C)(C)C1)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Cl-].O
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

MitoTEMPO is a mitochondria-targeted antioxidant that possesses superoxide and alkyl radical scavenging properties[1]. This compound combines the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, which allows it to pass through lipid bilayers and accumulate in mitochondria.1 Mitochondrial targeting of superoxide scavenging via mitoTEMPO has been examined for potential therapeutic benefit to a variety of mitochondrial dysfunctions arising from excessive reactive oxygen species[2-4].

References：

[1]. Dikalov S. Cross talk between mitochondria and NADPH oxidases. Free Radical Biology and Medicine, 2011, 51(7): 1289-1301.

[2]. Liang H L, Arsenault J R, Mortensen J, et al. Partial attenuation of cytotoxicity and apoptosis by SOD1 in ischemic renal epithelial cells. Apoptosis, 2009, 14(10): 1176-1189.

[3]. Dikalova A E, Bikineyeva A T, Budzyn, K, et al. Therapeutic targeting of mitochondrial superoxide in hypertension. Circulation Research, 2010, 107(1): 106-116.

[4]. Liang H L, Sedlic F, Bosnjak Z J, et al. SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis, and mitochondrial apoptosis after ATP depletion recovery. Free Radical Biology and Medicine, 2010, 49(10): 1550-1560.