您好，欢迎来到试剂信息网！ [登录] [免费注册]
试剂信息网
发布求购
位置：首页 > 产品库 > Arachidonic Acid(sodium salt)
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Arachidonic Acid(sodium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Arachidonic Acid(sodium salt)图片
CAS NO:6610-25-9
包装与价格：
包装价格(元)
25mg电议
50mg电议
100mg电议
500mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt326.45
Cas No.6610-25-9
FormulaC20H31NaO2-
Solubility≤1.5mg/ml in ethanol
Chemical NameA name could not be generated for this structure.
Canonical SMILESCCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC([O-])=O.[Na]
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Arachidonic acid (sodium salt) is an essential fatty acid [1].

Arachidonic acid is an integral constituent of cell membrane, rendering it with fluidity and flexibility, so necessary for the function of all cells, especially in nervous system, skeletal muscle, and immune system. In its free form, arachidonic acid modulates the function of ion channels, several receptors and enzymes, via activation as well as inhibition [1].

Arachidonic acid at the concentration of 5 mM, irreversibly killed 1-, 3-, 4-, 5-, and 6-week-oldSchistosoma mansoni (S. mansoni) and 9-, 10-, and 12-week-oldSchistosoma haematobium (S. haematobium) worms within 3 to 4 h [2]. In PC-3 prostate cancer cells, arachidonic acid (0, 0.1, 0.5, 5 or 10 μg/ml) induced expression ofcox-2,cPLA2 andc-fos message in a dose-dependent manner. Furthermore, proliferation of human prostate cells was significantly increased 48 h after arachidonic acid addition [3].

In BALB/c or C57BL/6 mice, a single oral dose of arachidonic acid (500 or 1000 mg/kg forS. mansoni, 1000 mg/kg forS. haematobium) led to a significant reduction of 31.2 to 39.3% in theS. mansoni and 57% in theS. haematobium total worm burden [2].

References:

[1]. Tallima H, El Ridi R. Arachidonic acid: Physiological roles and potential health benefits - A review. Journal of Advanced Research, 2017, 11: 33-41.

[2]. El Ridi R, Aboueldahab M, Tallima H, et al. In vitro and in vivo activities of arachidonic acid against Schistosoma mansoni and Schistosoma haematobium. Antimicrobial Agents and Chemotherapy, 2010, 54(8): 3383-3389.

[3]. Hughes-Fulford M, Tjandrawinata R R, Li C F, et al. Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. Carcinogenesis, 2005, 26(9): 1520-1526.