DL-threo-PPMP(hydrochloride)

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

139974-41-7

包装与价格：

包装	价格(元)
25mg	电议
50mg	电议
100mg	电议

产品介绍

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	511.2
Cas No.	139974-41-7
Formula	C₂₉H₅₀N₂O₃·HCl
Synonyms	DL-threo-1-Phenyl-2-palmitoylamino-3-morpholino-1-propanol
Solubility	≤10mg/ml in ethanol;20mg/ml in DMSO;5mg/ml in dimethyl formamide
Chemical Name	rel-N-[(1R,2R)-2-hydroxy-1-(4-morpholinylmethyl)-2-phenylethyl]-hexadecanamide, monohydrochloride
Canonical SMILES	O=C(CCCCCCCCCCCCCCC)N[C@H](CN1CCOCC1)[C@H](O)C2=CC=CC=C2.Cl
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

DL-threo-PPMP (hydrochloride) is an inhibitor of glucosylceramide synthase [1].

Glucosylceramide synthase (GCS) is a pervasive enzyme inherent to intracellular ceramide metabolism. The enzyme has been involved in catalyzing the transfer of glucose to ceramide, which is the principle committed step in glycolipid biosynthesis. GCS has been involved in the cytotoxic response of cancer cells to chemotherapy. Glucosylceramide synthase-based sphingolipids have been identified as important mediators of a variety of cellular functions, including proliferation, differentiation, development, and cell-cell recognition [2].

DL-threo-PPMP was a ceramide analog. DL-threo-PPMP inhibited the activity of glucosylceramide synthase with an IC50 value between 2 and 20 μM. It has been used to study the role of glucosylceramide synthase in cell growth, apoptosis, and autophagy [1].

References:
[1] Lee L, Abe A, Shayman J A. Improved inhibitors of glucosylceramide synthase[J]. Journal of Biological Chemistry, 1999, 274(21): 14662-14669.
[2] Bleicher R J, Cabot M C. Glucosylceramide synthase and apoptosis[J]. Biochimica et biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2002, 1585(2): 172-178.