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Pirlimycin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pirlimycin图片
CAS NO:79548-73-5
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at -20°C
M.Wt411
Cas No.79548-73-5
FormulaC17H31ClN2O5S
SynonymsU-57930E
SolubilitySoluble in ethanol;Soluble in methanol;Soluble in DMSO;Soluble in dimethyl formamide
Chemical Namemethyl 7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-4-ethyl-2-piperidinyl]carbonyl]amino]-1-thio-L-threo-α-D-galacto-octopyranoside
Canonical SMILESCC[C@@H]1CCN[C@H](C(N[C@@]([C@@H](Cl)C)([H])[C@@]2([H])O[C@H](SC)[C@H](O)[C@@H](O)[C@H]2O)=O)C1
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Pirlimycin, a lincosamide antibiotic, is effective against gram-positive bacteria, including Staphylococcus, Bacteroides, Streptococcus, and Plasmodium. It functions via inhibiting protein synthesis in bacteria by inducing premature dissociation of the peptidyl-tRNA from the ribosome.

In vitro: Pirlimycin showed activity against Helicobacter pylori with a minimal inhibitory concentration [MIC] 50 of 4 μg/ml and an MIC90 of 64 μg/ml [1].

In vivo: Cows were treated with 50 mg of pirlimycin via two intramammary infusions per quarter at a 24- hour interval (2-day) for 2, 5, or 8 days. Pirlimycin showed antibiotic therapy against environmental Streptococcus spp and Staphylococcus aureus intramammary individual and combined infections [1]. Specifically, pirlimycin cured environmental Streptococcus spp infections in 66.7% (14/21), 85% (17/20), 100% (14/14) in the 2-day group, 5-day group and 8-day group, respectively. S. aureus infections were cured by the treatment of pirlimycin in 13.3% (2/15), 31.3% (5/16), 83.3% (5/6) in the 2-day group, 5-day group and 8-day group, respectively. Furthermore, S. aureus, S. dysgalactiae subsp dysgalactiae, and Enterococcus spp intramammary infections were eliminated by the extended treatment of pirlimycin in 8-day group [2].

References:
[1].  Westblom, T., Midkiff, B., & Czinn, S. In vitro susceptibility ofHelicobacter pylori to trospectomycin, pirlimycin (U-57930E), mirincamycin (U-24729A) and N-demethyl clindamycin (U-26767A). European Journal of Clinical Microbiology & Infectious Diseases. 1993; 12(7): 560-562.
[2].  B. E. Gillespie, H. Moorehead, P. Lunn, H. H. Dowlen, D. L. Johnson, K. C. Lamar, M. J. Lewis, S. J. Ivey, J. W. Hallberg, S. T. Chester, and S. P. Oliver. Efficacy of extended pirlimycin hydrochloride therapy for treatment of environmental Streptococcus spp and Staphylococcus aureus intramammary infections in lactating dairy cows. Veterinary Therapeutics. 2002; 3(4): 373-80.