| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
Cell experiment: | Chondrocytes are isolated from articular cartilage of donors with no articular disease. Unstimulated and interleukin 1 (IL-1) stimulated chondrocytes are used as models to study the effects of drugs on COX-1 and COX-2. Cells are incubated with vehicle or drugs (Asprin); supernatants are removed and the level of prostaglandin E2 (PGE2) in each sample is determined by enzyme immunoassay. IC50s are calculated from the reduction in PGE2 content by different concentrations of the test substance by linear regression analysis[5]. |
| 产品描述 | Aspirin (Acetylsalicylic acid) is a potent and selective inhibitor of cyclooxygenase (COX) with a broad range of pharmacological activities including anti-inflammation and pain relief. Multiple studies have accumulated sufficient evidence to establish the association between the use of aspirin and a reduced risk of cancers including prostate cancer, breast cancer, colorectal cancer, endometrial cancer, and ovarian cancer. Aspirin suppresses ovarian cancer cells harboring COX-1 by acting as histone deacetylase inhibitors to up-regulate cell cycle arrest protein p21. Aspirin also inhibits the expression of COX-2 in human umbilical vein endothelial cells and neonatal rat ventricular cardiomyocytes resulting in reduced PG production and the down-regulation of ERK and NF-KB respectively. Reference [1].Cho M, Kabir SM, Dong Y, Lee E, Rice VM, Khabele D, Son DS. Aspirin Blocks EGF-stimulated Cell Viability in a COX-1 Dependent Manner in Ovarian Cancer Cells. J Cancer. 2013;4(8):671-678. |
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