| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| Purity | Greater than 96.0% as determined by RP-HPLC. |
| Phycical Appearance | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Shipping Condition | Shipped at Room temp. |
| Synonyms | GLP1; GLP2; GRPP. |
| Amino Acid Sequence | His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH. |
| Solubility | It is recommended to reconstitute the lyophilized Glucagon in a sterile 1% HCl solution at a concentration of 0.1-1 mg/ml, which can then be further diluted to other aqueous solutions. |
| Formulation | Glucagon peptide was formulated with no additives. |
| Introduction | Glucagon is an important hormone involved in carbohydrate metabolism. The hormone is synthesized and secreted from alpha cells (?-cells) of the islets of Langerhans, which are located in the endocrine portion of the pancreas. Glucagon is released when the glucose level in the blood is low (hypoglycemia), causing the liver to convert stored glycogen into glucose and release it into the bloodstream. The action of glucagon is thus opposite to that of insulin, which instructs the body's cells to take in glucose from the blood in times of satiation.Glucagon is beneficial for the culture of some cell types. It has been used in some biochemical regulation studies of glycogenolysis in hepatocytes. It has been also been found to induce DNA replication in primary cultures of adult rat hepatocytes when used in combinations with EGF and Insulin. Glucagon increases the blood glucose concentration by promoting rapid breakdown of liver glycogen, and also acts to relax smooth muscle such as the gastrointestinal tract. |
| Stability | Glucagon although stable at room temperature for 3 weeks, should be stored desiccated below -18℃ . Upon reconstitution Glucagon should be stored at 4℃ between 2-7 days and for future use below -18℃ .For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| 产品描述 | Glucagon is a 29 amino acid peptide that is secreted from pancreatic α-cells in response to low levels of blood glucose[2]. The best-described effect of glucagon is its action on the liver, where it increases blood glucose through stimulation of gluconeogenesis and glycogenolysis[1]. The non-glycemic effects of glucagon include the regulation of food intake and satiety, lipid homeostasis, insulin secretion and energy expenditure[3]. Glucagon, at concentrations of 0.3 and 3 uM, inhibited the chemotactic response of neutrophils towards all chemoattractants tested[4]. Glucagon may promote insulin secretion in MIN6 cells by reducing the production of cGMP in MIN6 cells and increasing the proliferative activity of MIN6 islet β cell line[8]. Thyroxine and glucagon can significantly reduce the mRNA transcription and protein expression levels of HSPs under high temperature conditions[9]. While using the non-invasive barometric plethysmography,glucagon (1 µg/kg, i.n.) significantly inhibited methacholine-induced bronchospasm in mice[5]. The effects of intraperitoneal glucagon injections on intake of a palatable milk diet were tested in rats maintained with ad lib access to pelleted diet. Injections of 25--800 micrograms/kg glucagon administered at meal onset inhibited meal size by 17--36%, but did not affect the normal postprandial behavioral satiety sequence or elicit any behavioral signs of toxicity[6]. Hepatic portal infusion of 13.6 micrograms glucagon/meal reduced the size of spontaneous meals both early and late in the dark in neurally intact rats, but not in hepatic-vagotomized rats[7]. References: |
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