Candesartan D4 (CV-11974 D4) 是氘标记的 Candesartan，它是一种血管紧张素 II 受体拮抗剂。
| Cas No. | 1346604-70-3 |
| 别名 | 坎地沙坦 D4; CV-11974-d4 |
| Canonical SMILES | OC(C1=CC=CC2=C1N(CC3=C([2H])C([2H])=C(C4=CC=CC=C4C5=NN=NN5)C([2H])=C3[2H])C(OCC)=N2)=O |
| 分子式 | C24H16D4N6O3 |
| 分子量 | 444.5 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 3 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Candesartan-d4 is intended for use as an internal standard for the quantification of candesartan by GC- or LC-MS. Candesartan is an inhibitor of the angiotensin II type 1 (AT1) receptor (Kis = 0.17, 0.12, and 0.12 nM for human AT1, rat AT1A, and rat AT1B recombinant receptors, respectively). It is selective for AT1 over AT2 receptors (Ki = 26,500 nM for the human recombinant AT2 receptor). It inhibits angiotensin II-induced contraction of isolated rabbit aortic strips and increases in blood pressure in rats following intravenous administration (ID50 = 0.033 mg/kg). Candesartan is a metabolite of the orally bioavailable prodrug candesartan cilexetil . Formulations containing candesartan have been used in the treatment of hypertension and heart failure. |
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