| 包装 | 价格(元) |
| 25ug | 电议 |
| 100ug | 电议 |
| 1mg | 电议 |
| Gene ID: | 3606 | Accession #: | Q14116 |
| Alternate Names: | Human IL-18, IL-18, IL18, IL 18, h-IL-18, rh-IL-18, recombinant human IL-18, recombinant IL-18, IL, interluekin. | ||
| Source: | Escherichia Coli. | M.Wt: | 18.3 kDa |
| Appearance: | Lyophilized protein | Storage: | Store at -20°C |
| Formulation: | Sterile filtered and lyophilized from PBS. | ||
| Solubility: | Reconstitute in ice-cold water to a concentration of 0.5-1 μg/μl. | ||
| Shipping Condition: | Blue ice. | Handling: | Centrifuge the vial prior to opening. |
| Usage: | For Research Use Only! Not to be used in humans. | ||
Interleukin-18 (IL-18) is a proinflammatory cytokine produced by monocyte/macrophages, osteoblasts and keratinocytes, as a proprotein which is proteolytically processed to its active form by caspase-1. Human IL-18 can enhance NK cell activity in PBMC cultures. Also, human IL-18 induces the production of IFN-γ and GM-CSF but inhibits the production of IL-10 by PBMC. IL-18 plays an important role in cell-mediated immune responses.
The human IL-18 cDNA encodes a 193 aa protein with a 36 aa propeptide. Recombinant human IL-18 is an 18 kDa single, non-glycosylated polypeptide chain containing 157 amino acids.
| Determined by dose-dependent stimulation of the IFN-γ by human PBMC co-stimulated with rh-IL-12. | ||||||
| ED50 | 5 ng/ml. | |||||
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