| CAS NO: | 162808-62-0 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 1092.33 |
| Cas No. | 162808-62-0 |
| Formula | C53H89N9O15 |
| Solubility | ≥48.1 mg/mL in DMSO |
| Chemical Name | (2R,6S,11R,12R,14aS,15S,20S,23S,25aS)-20-((R)-3-amino-1-hydroxypropyl)-12-((2-aminoethyl)amino)-23-((1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl)-9-(11,13-dimethyl-2-oxopentadecyl)-2,11,15-trihydroxy-6-((R)-1-hydroxyethyl)hexadecahydro-1H-dipyrrolo[2,1- |
| Canonical SMILES | O=C([C@@H]1C[C@@H](O)CN1C([C@@H](NC(C2CC(CCCCCCCCC(C)CC(CC)C)=O)=O)[C@@H](C)O)=O)N[C@@H]([C@H](O)[C@@H](O)C3=CC=C(O)C=C3)C(N[C@@H]([C@H](O)CCN)C(N4CC[C@H](O)[C@H]4C(N[C@@H](NCCN)[C@H](O)C2)=O)=O)=O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Caspofungin is an inhibitor ofβ-1,3-glucan synthase with IC50 value of 0.6 nmol/L in membrane preparations ofC. albicans[1, 2].
β-1,3-glucan synthase plays a critical role in biosynthesis ofβ-(1,3)-D-glucan, an essential cell wall component of many pathogenic fungi that is absent in the mammalian host. Inhibition ofβ-1,3-glucan synthase provides a potential therapeutic option for treating serious and life-threatening fungal infections [1].
Caspofungin exhibited inhibitory effect against 400 bloodstreamCandidaspecies with MIC90 value of 0.25 μg/mL. Moreover, all azole-resistant isolates were susceptible to Caspofungin at concentrations of ≤ 0.5 μg/mL. In addition, Caspofungin showed a postantifungal effect againstC. albicans, which lasted for 6 ~ 8 h, at concentrations of 0.125 ~ 1 μg/mL [2].
In 140 patients with mucosal candidiasis, 63% of whom had esophageal involvement and 98% of whom had acquired immunodeficiency syndrome (AIDS), the response rates among the Caspofungin recipients (35, 50, or 70 mg, i.v., q.d., for 7 ~ 14 d) with exclusively oropharyngeal infections was 84% ~ 93%, higher than 67% among those assigned to receive Amphotericin B (0.5 mg/kg, i.v., q.d., for 7 ~ 14 d) [2].
References:
[1]. Leonard W R Jr, Belyk K M, Conlon D A, et al. Synthesis of the antifungal beta-1,3-glucan synthase inhibitor CANCIDAS (caspofungin acetate) from pneumocandin B0. The Journal of Organic Chemistry, 2007, 72(7): 2335-2343.
[2]. Deresinski S C, Stevens D A. Caspofungin. Clinical Infectious Diseases, 2003, 36(11): 1445-1457.
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