| CAS NO: | 1374772-61-8 |
| 包装: | 1mg |
| 市场价: | 2419元 |
| Cas No. | 1374772-61-8 |
| Canonical SMILES | [H][C@]1(CCCN1C([C@H](CC2=CC=C(O)C=C2)NC([C@]3([H])CSC([C@H](CC4=CC=CC=C4)NC5=O)=N3)=O)=O)C6=NC(C7=NC(C8=NC(C9=NC(C(NC(C(N[C@@H](C)C(N%10[C@H](C(NC(C(NC(C(N)=O)=C)=O)=C)=O)CCC%10)=O)=O)=C)=O)=CS9)=CC=C8C%11=NC(C(N[C@@H](CC(N)=O)C%12=NC5=CS%12)=O)=C(C)O%11)=CS7)=CS6 |
| 分子式 | C69H66N18O13S5 |
| 分子量 | 1515.7 |
| 溶解度 | Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Kocurin is a thiazolyl peptide originally isolated fromK. palustrisand has antibiotic activity.1It is active against methicillin-resistantS. aureus(MRSA; MIC = 0.25 µg/ml), as well asB. subtilisandE. faeciumin a solid agar test when used at a concentration of 8 µg/ml. Kocurin is also active againstE. faecium,E. faecalis,S. epidermidis, and clinical isolates of vancomycin-resistant enterococci (MICs = 0.004-1.025 µg/ml).2In vivo, kocurin (2.5, 5, and 10 mg/ml) increases survival in a mouse model ofE. faecium-induced septicemia. It decreases the number of colony forming units (CFUs) in a mouse model of MRSA lung infection. 1.Martin, J., da S. Sousa, T., Crespo, G., et al.Kocurin, the true structure of PM181104, an anti-methicillin-resistant Staphylococcus aureus (MRSA) thiazolyl peptide from the marine-derived bacterium Kocuria palustrisMar. Drugs11(2)387-398(2013) 2.Mahajan, G., Thomas, B., Parab, R., et al.In vitro and in vivo activities of antibiotic PM181104Antimicrob. Agents Chemother.57(11)5315-5319(2013) |
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