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(S)-Methylisothiourea sulfate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(S)-Methylisothiourea sulfate图片
CAS NO:867-44-7
包装与价格：
包装价格(元)
10mM (in 1mL H2O)电议
10mg电议
50mg电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at RT
M.Wt278.36
Cas No.867-44-7
FormulaC4H14N4O4S3
Solubilityinsoluble in EtOH; insoluble in DMSO; ≥11.9 mg/mL in H2O
Chemical Namemethyl carbamimidothioate hemisulfate
Canonical SMILESNC(SC)=N.NC(SC)=N.OS(O)(=O)=O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

(S)-Methylisothiourea sulfate is a potent, selective and competitive inhibitor of the inducible nitric oxide synthase (iNOS). Nitric oxide synthases, composed of the constitutive and the inducible isoforms, are a family of enzymes responsible for catalyzing the production of nitric oxide (NO) from L-arginine. The inducible isoform, i.e. iNOS, can be induced in various cells, including macrophages, by a variety of agents such as endotoxin, and thereby produces NO as an immune defense mechanism. Enhanced NO formation has been implied in the pathophysiology of a variety of diseases, such as circulatory shock. Thus, (S)-methylisothiourea sulfate, as a selective iNOS inhibitor, may have considerable value in the therapy of circulatory shock of various etiologies and other pathophysiological conditions associated with induction of iNOS.

Reference:

1. Szabó C, Southan GJ, Thiemermann C. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91(26): 12472-12476.

试验操作

Cell experiment:[1]

Cell lines

J774.2 macrophages and rat aortic vascular smooth muscle cells

Reaction Conditions

100 nM ~100 μM (S)-methylisothiourea sulfate

Applications

In J774.2 macrophages and rat aortic vascular smooth muscle cells, (S)-methylisothiourea sulfate exhibited more potent inhibitory effects on lipopolysaccharide (LPS)-induced nitrite production than any other known inhibitor of NOS, such as NG-amino-L-arginine.

Animal experiment:[1]

Animal models

Male Wistar rats, 260 ~ 320 g

Dosage form

0.01 ~ 3 mg/kg

Intravenous administration

Applications

S-Methylisothiourea sulfate dose-dependently reversed the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin LPS in anesthetized rats.

Note

The technical data provided above is for reference only.

References:

1. Szabó C, Southan GJ, Thiemermann C. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America, 1994, 91(26): 12472-12476.