| CAS NO: | 1215821-44-5 |
| 包装: | 1mg |
| 市场价: | 5670元 |
| Cas No. | 1215821-44-5 |
| 别名 | MDL-16455-d10 hydrochloride; Terfenadine carboxylate-d10 hydrochloride |
| Canonical SMILES | OC(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])C3CCN(CCCC(O)C4=CC=C(C(C)(C)C(O)=O)C=C4)CC3.Cl |
| 分子式 | C32H29D10NO4.HCl |
| 分子量 | 548.2 |
| 溶解度 | Methanol: Slightly Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Fexofenadine-d10is intended for use as an internal standard for the quantification of fexofenadine by GC- or LC-MS. Fexofenadine is a histamine H1receptor antagonist (Ki= 10 nM).1It reverses contraction of isolated rat tracheal strips induced by acetyl-β-methylcholine .2Fexofenadine inhibits expression of IL-8 in TNF-α-stimulated HCT116 and COLO 205 cells.3Oral administration of fexofenadine (2 and 10 mg/kg) reduces severity of colitis and phospho-IκB kinase activation in a mouse model of colitis induced by dextran sulfate sodium . 1.Church, M.K., and Church, D.S.Pharmacology of antihistaminesIndian J. Dermatol.58(3)219-224(2013) 2.Lai, W.S., Lin, Y.Y., Chu, Y.H., et al.Efficacy of fexofenadine in isolated rat tracheasRhinology51(4)376-380(2013) 3.Koh, S.J., Kim, J.W., Kim, B.G., et al.Fexofenadine regulates nuclear factor-κB signaling and endoplasmic reticulum stress in intestinal epithelial cells and ameliorates acute and chronic colitis in miceJ. Pharmacol. Exp. Ther.352(3)455-461(2015) |
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