| CAS NO: | 1216953-13-7 |
| 包装: | 1mg |
| 市场价: | 2948元 |
| Cas No. | 1216953-13-7 |
| 别名 | 依巴斯汀 d5 |
| Canonical SMILES | O=C(C1=CC=C(C(C)(C)C)C=C1)CCCN(CC2)CCC2OC(C3=CC=CC=C3)C4=C([2H])C([2H])=C([2H])C([2H])=C4[2H] |
| 分子式 | C32H34D5NO2 |
| 分子量 | 474.7 |
| 溶解度 | Methanol: slightly, heated |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ebastine-d5is intended for use as an internal standard for the quantification of ebastine by GC- or LC-MS. Ebastine is a potent second generation histamine H1receptor antagonist (IC50= 45 nM) that does not cross the blood brain barrier.1It undergoes extensive first-pass metabolism by hepatic cytochrome P450 3A4 into its active carboxylic acid metabolite, carebastine , which exerts most of the pharmacological effects.2At 10 μM, ebastine has been shown to inhibit T cell proliferation and the production of Th2-type pro-inflammatory cytokines by macrophages.3 1.Abou-Gharbia, M., Moyer, J.A., Nielsen, S.T., et al.New antihistamines: Substituted piperazine and piperidine derivatives as novel H1-antagonistsJ. Med. Chem.38(20)4026-4032(1995) 2.Vincent, J., Liminana, R., Meredith, P.A., et al.The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjectsBr. J. Clin. Pharmacol.26(5)497-502(1988) 3.Nori, M., Iwata, S., Munakata, Y., et al.Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokinesClin. Exp. Allergy33(11)1544-1554(2003) |
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