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CU-115
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CU-115图片
CAS NO:2471982-20-2
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
CU-115 是一种有效的 TLR8 拮抗剂 (IC50=1.04 μM)，对 TLR8 的选择性优于 TLR7 (IC50=>50 μM)。
Cas No.2471982-20-2
Canonical SMILESO=C(NC1=CC=C(OC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C=C1)C3=C(I)C=CC=C3F
分子式C21H11F7INO2
分子量569.2
溶解度DMF: 10mg/mL,DMSO: 10mg/mL,DMSO:PBS (pH 7.2) (1:5): 0.15mg/mL,Ethanol: 0.25mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CU-115 is a toll-like receptor 8 (TLR8) antagonist (IC50= 1.04 µM).1It is selective for TLR8 over TLR7 (IC50= >50 µM). CU-115 inhibits increases in type I IFN transcriptional activity induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD in a luciferase reporter assay when used at concentrations of 5 and 20 µM. It decreases TNF-α and IL-1β production induced by R-848 in THP-1 cells when used at a concentration of 5 µM.

1.Padilla-Salinas, R., Anderson, R., Sakaniwa, K., et al.Discovery of novel small molecule dual inhibitors targeting toll-like receptors 7 and 8J. Med. Chem.62(22)10221-10244(2019)