Naspm trihydrochloride

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CAS NO:

1049731-36-3

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议

产品介绍

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	479.91
Cas No.	1049731-36-3
Formula	C₂₂H₃₄N₄O·3HCl
Solubility	Soluble to 100 mM in sterile water
Chemical Name	N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide trihydrochloride
Canonical SMILES	O=C(CC1=CC=CC2=CC=CC=C12)NCCCNCCCCNCCCN.Cl.Cl.Cl
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Naspm trihydrochloride is a selective antagonist of Ca²⁺-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors. AMPA receptors are glutamate-gated ion channels that play central roles in the mammalian brain, mediating fast excitatory synaptic transmission and underlying several forms of synaptic plasticity. On excitatory neurons in adult animals, two types of AMPA receptors are primarily expressed, namely heteromeric channels composed of GluR1 and GluR2 subunits (GluR1/2 receptors), as well as channels composed of GluR2 and GluR3 subunits (GluR2/3 receptors). Naspm trihydrochloride blocks AMPA receptors lacking the GluR2 subunit, with an IC50 value of 0.3 μM for GluR1 homomers.

References:

1. Nilsen A, England PM. A subtype-selective, use-dependent inhibitor of native AMPA receptors. Journal of the American Chemical Society, 2007, 129(16): 4902-4903.

2. Koike M, Iino M, Ozawa S. Blocking effect of 1-naphthyl acetyl spermine on Ca²⁺-permeable AMPA receptors in cultured rat hippocampal neurons. Neuroscience Research, 1997, 29(1): 27-36.

试验操作

Cell experiment:[2]
Cell lines	Rat hippocampal neurons
Reaction Conditions	0.01 ~ 10 μM Naspm trihydrochloride
Applications	Naspm trihydrochloride (3 μM) selectively inhibited the strong inward rectification and Ca²⁺-permeable AMPA receptors expressed in type Ⅱ neurons, but showed no effect on AMPA receptors in type Ⅰ neurons. At -60 mV, Naspm trihydrochloride suppressed AMPA receptors in type Ⅱ neurons, with an IC50 value of 0.33 μM. The blocking effect of Naspm trihydrochloride on the Ca²⁺-permeable AMPA receptors was dose- and voltage-dependent.
Note	The technical data provided above is for reference only.
	References: 1. Nilsen A, England PM. A subtype-selective, use-dependent inhibitor of native AMPA receptors. Journal of the American Chemical Society, 2007, 129(16): 4902-4903. 2. Koike M, Iino M, Ozawa S. Blocking effect of 1-naphthyl acetyl spermine on Ca²⁺-permeable AMPA receptors in cultured rat hippocampal neurons. Neuroscience Research, 1997, 29(1): 27-36.