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Tiaprofenic Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tiaprofenic Acid图片
CAS NO:33005-95-7
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
噻洛芬酸是一种具有抗炎和镇痛功效的口服活性非甾体抗炎药 (NSAID)。
Cas No.33005-95-7
别名噻洛芬酸
Canonical SMILESO=C(C1=CC=C(C(C)C(O)=O)S1)C2=CC=CC=C2
分子式C14H12O3S
分子量260.3
溶解度DMF: 15mg/mL,DMSO: 20mg/mL,Ethanol: 20mg/mL,Ethanol:PBS (pH 7.2) (1:10): 0.09mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tiaprofenic acid is a COX inhibitor and a non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic activities.1 It inhibits synthesis of prostaglandin E2 and PGF2α from arachidonic acid in bovine seminal vesicle microsomes and inhibits thromboxane B2 formation in human umbilical cord arteries bathed in clotting human blood (IC50 = 0.71 μM).2,1 Tiaprofenic acid has anti-inflammatory activity in rat models of carrageenan-induced edema and adjuvant-induced arthritis and has analgesic activity in acetic acid- or phenylquinone-induced writhing tests in rodents.1

References
1. Sorkin, E.M., and Brogden, R.N. Tiaprofenic acid. A review of its pharmacological properties and therapeutic efficacy in rheumatic diseases and pain states. Drugs 29(3), 208-235 (1985).
2. Schr•r, K., and Seidel, H. Blood-vessel wall arachidonate metabolism and its pharmacological modification in a new in vitro assay system. Naunyn Schmiedebergs Arch. Pharmacol. 337(2), 177-182 (1988).