Hypoxanthine

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Hypoxanthine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	68-94-0
包装:	50mg
市场价:	350元

产品介绍

化学性质

Physical Appearance	A solid
Storage	Store at -20°C
M.Wt	136.11
Cas No.	68-94-0
Formula	C₅H₄N₄O
Solubility	insoluble in EtOH; insoluble in H2O; ≥1.36 mg/mL in DMSO with ultrasonic; ≥5.89 mg/mL in EtOH with ultrasonic
Canonical SMILES	O=C1N=CNC2=C1NC=N2
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Hypoxanthine is a natural purine derivative, with potential to be used as a free radical generator. Hypoxanthine seems to play a role in posthypoxic reoxygenation cell injury via oxygen radical production, and is thus involved in the pathogenesis of many diseases. Hypoxanthine also modulates a variety of other processes because it can react with benzodiazepine receptors and inhibit phosphodiesterase in the brain. Hypoxanthine has been reported to be used as an indicator of hypoxia.

References:

1. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatric Research, 1988, 23(2): 143-150.

2. Skolnick P, Marangos PJ, Goodwin FK, et al. Identification of inosine and hypoxanthine as endogenous inhibitors of [³H] diazepam binding in the central nervous system. Life Sciences, 1978, 23(14): 1473-1480.

试验操作

Cell experiment:[2]
Cell lines	Rat cerebral cortex synaptosomes
Reaction Conditions	400 μM
Applications	Hypoxanthine alone inhibited [3H] diazepam binding by 11.7%. When hypoxanthine was combined with inosine, the inhibition on [³H] diazepam binding could reach 34.3%. Thus, hypoxanthine could play a neuromodulatory role as well as affect benzodiazepine action.
Note	The technical data provided above is for reference only.
	References: 1. Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatric Research, 1988, 23(2): 143-150. 2. Skolnick P, Marangos PJ, Goodwin FK, et al. Identification of inosine and hypoxanthine as endogenous inhibitors of [³H] diazepam binding in the central nervous system. Life Sciences, 1978, 23(14): 1473-1480.