| CAS NO: | 53-84-9 |
| 包装 | 价格(元) |
| 10mM (in 1mL H2O) | 电议 |
| 1g | 电议 |
| 5g | 电议 |
| Storage | Store at -20°C |
| M.Wt | 663.43 |
| Cas No. | 53-84-9 |
| Formula | C21H27N7O14P2 |
| Solubility | ≥28.55 mg/mL in H2O; insoluble in EtOH; ≥26.05 mg/mL in DMSO |
| Chemical Name | [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate |
| Canonical SMILES | O[C@H]([C@@H](CO[P@@](O[P@](OC[C@@H]1[C@@H](O)[C@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O)=O)([O-])=O)O[C@H]4[N+]5=CC=CC(C(N)=O)=C5)[C@H]4O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
NAD+is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is often used as a starting point for inhibitor design, a set of 14 analogs with natural NAD+substrate can weakly inhibit NAD glycohydrolase (NADase) activity of CD38 (2 mM < IC50 < 10 mM)[1].
NAD+, also called nicotinamide adenine dinucleotide, act as a signaling molecule and a cofactor or substrate for enzymatic activities.
NAD+ is an oxidizing agent which accepts electrons from other molecules and reduces to NADH[2]. NAD+also plays important roles in the activity of several enzymes such as poly (ADP) – ribose polymerases and cADP – ribose synthases, it can be used by some sirtuins to participate in protein deacetylation mediation, which produce O-acetyl-ADP-ribose and nicotinamide as well as the deacetylated protein[3].
Oral NAD+ supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia[4].
References:
[1]. Division of Biophysics, et al. NAD Analogs in Aid of Chemical Biology and Medicinal Chemistry. Molecules 2019, 24(22), 4187.
[2]. Houtkooper RH1, Cantó C, Wanders R.J., et al. The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways. Endocr. Rev. 2010, 31(2), 194-223.
[3]. Schwer B, Verdin E. Conserved metabolic regulatory functions of sirtuins. Cell Metab. 2008, 7, 104-112.
[4]. Kussmaul, L. and J. Hirst, The mechanism of superoxide production by NADH: ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A, 2006. 103(20): p. 7607-12.
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