| 包装 | 价格(元) |
| 1g | 电议 |
| 5g | 电议 |
Cell lines | HepG2 cell line |
Preparation Method | Effects of Oleic acid (9-cis-Octadecenoic acid) and EPA on PA-induced inhibition of HepG2 cell viability HepG2 cells were incubated for 12 h in the absence or presence of 0.5 mM PA and various concentrations (0 0.4 mM) of Oleic acid (9-cis-Octadecenoic acid) or EPA. |
Reaction Conditions | 0 - 0.4 mM Oleic acid (9-cis-Octadecenoic acid) for 12 hrs |
Applications | Oleic acid (9-cis-Octadecenoic acid) attenuates PA-induced apoptosis through OA-activated autophagy. |
Animal models | Male Swiss mouse weighing about 25-30 grams |
Preparation Method | Mouse ear was topically treated after UVB irradiation with semisolid formulations (15 mg/ear inculding Oleic acid (9-cis-Octadecenoic acid)), with the aid of a spatula, according to the experimental groups. |
Dosage form | 0.3%-3% Oleic acid (9-cis-Octadecenoic acid) in semisolid formulations for 24-72h |
Applications | Pemulen 3% Oleic acid (9-cis-Octadecenoic acid) and dexamethasone also reduced inflammatory cell infiltration. |
| 产品描述 | Oleic acid (9-cis-Octadecenoic acid) is a monounsaturated Omega-9 fatty acid found in plants and animals[1]. It is a Na+/K+ ATPase activator[2]. Oleic acid (9-cis-Octadecenoic acid) or EPA treatment alone inhibited cell viability, similar to PA treatment, but PA and OA (PA+OA) or combined PA and EPA (PA+EPA) treatment increased cell viability in HepG2 cells compared with PA treatment alone PA+OA.The growth and proliferation effects of the treatment are consistent with previous observations that Oleic acid (9-cis-Octadecenoic acid) attenuates PA-induced apoptosis through OA-activated autophagy[4]. Oleic acid (9-cis-Octadecenoic acid) and palmitic acid can induce lipid deposition in HepG2 cells and increase expression of every component of mTOR/S6K1/SREBP-1c pathway[3]. Oleic acid (9-cis-Octadecenoic acid) caused a concentration- and time-dependent damage with typical apoptotic features in cortical and hippocampal cultures from embryonic and neonatal rats, respectively, as well as in human neuroblastoma SH-SY5Y cells[7]. Oleic acid (9-cis-Octadecenoic acid) in semisolids, especially Pemulen TR2-based ones, presented suitable characteristics for cutaneous administration and its anti-inflammatory activity seems to occur via glucocorticoid receptors. Oleic acid (9-cis-Octadecenoic acid) was also capable to reduce croton oil-induced skin inflammation. Besides, the ex vivo skin permeation study indicated that OA reaches the receptor medium, which correlates with a systemic absorption in vivo[5].In mice,the reduction of dopamine and oxidant effect during cytarabine treatment could result in brain injury but could be prevented by Oleic acid (9-cis-Octadecenoic acid)supplementation[6]. References: |
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