| CAS NO: | 1311136-84-1 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 25mg | 电议 |
| Cas No. | 1311136-84-1 |
| 化学名 | (5R)-5-ethyl-3-(6-{[4-methyl-3-(methyloxy)phenyl]oxy}-3-pyridinyl)-2,4-imidazolidinedione |
| Canonical SMILES | O=C1N(C2=CC=C(OC3=CC=C(C)C(OC)=C3)N=C2)C([C@@H](CC)N1)=O |
| 分子式 | C18H19N3O4 |
| 分子量 | 341.367 |
| 溶解度 | DMSO : ≥ 250 mg/mL (732.36 mM) |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | AUT1 (AUT-1) is a novel specific, cell permeant modulator of Kv3 channels with EC50 of 4.7 and 4.9 uM for Kv3.1b and Kv3.2a, respectively; displays approximately 10-fold lower potency for Kv3.3 channels, and does not interact with a wide range of ion channels, receptors, and transporters; increases hKv3.1b and hKv3.2a currents by 1049 ± 198% and 226 ± 39%, respectively, at 30 uM; rescue the fast firing capability of FS interneurons following a reduction in Kv3 channel availability, has the potential to rescue normal function and therapeutic benefit in disorders like schizophrenia or age-related cognitive decline. Reference： [1]. Rosato-Siri MD, et al. J Pharmacol Exp Ther. 2015 Sep;354(3):251-60. [2]. Brown MR, et al. J Neurophysiol. 2016 Jul 1;116(1):106-21. [3]. Parekh PK, et al. Neuropsychopharmacology. 2018 Jan;43(2):435-444. |
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