VU0071063 是一种有效且特异性的 Kir6.2/SUR1 开放剂 (EC50=7.44 μM)，可用于研究在胰腺和大脑中表达的 Kir6.2/SUR1。
| Cas No. | 333415-38-6 |
| 化学名 | 7-[[4-(1,1-dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione |
| Canonical SMILES | CN(C(N1C)=O)C2=C(N(CC3=CC=C(C(C)(C)C)C=C3)C=N2)C1=O |
| 分子式 | C18H22N4O2 |
| 分子量 | 326.4 |
| 溶解度 | DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 20 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | VU0071063 is a potent and selective activator of the inward-rectifier potassium channel (Kir) 6.2 and sulfonylurea receptor (SUR) 1 (EC50 = 7 uM using whole cell patch clamp electrophysiology). It is selective for SUR1-containing Kir6.1 or Kir6.2 channels over SUR2A, Kir2.1, Kir2.2, Kir2.3, Kir3.1/3/2, and voltage-gated potassium channel 2.1. VU0071063 inhibits glucose-stimulated calcium entry in isolated mouse pancreatic β-cells. |
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